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Shigehiko Mizutani Selected Research

Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)

11/2013New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor.
1/2012Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension.
1/2011Placental leucine aminopeptidase- and aminopeptidase A- deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia.
9/2008New insights into the importance of aminopeptidase A in hypertension.
4/2005Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats.
8/2004Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.
5/2004Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor.
8/2003Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.
1/2003Hypertension and angiotensin II hypersensitivity in aminopeptidase A-deficient mice.
11/2002Effects of age, hypertension and HRT on serum aminopeptidase A activity.
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Shigehiko Mizutani Research Topics

Disease

19Carcinoma (Carcinomatosis)
07/2007 - 01/2002
17Neoplasms (Cancer)
02/2010 - 01/2003
9Pre-Eclampsia (Preeclampsia)
01/2022 - 04/2002
9Choriocarcinoma
04/2006 - 01/2002
8Endometrial Neoplasms (Endometrial Cancer)
01/2007 - 08/2003
7Adenocarcinoma
01/2007 - 01/2003
6Hypertension (High Blood Pressure)
01/2012 - 11/2002
4Ovarian Neoplasms (Ovarian Cancer)
12/2021 - 12/2003
4Endometrioid Carcinoma
01/2006 - 03/2003
3Premature Obstetric Labor (Premature Labor)
11/2013 - 01/2011
3Ovarian Epithelial Carcinoma
02/2010 - 04/2003
2Hypoxia (Hypoxemia)
11/2013 - 09/2009
2Hypersensitivity (Allergy)
05/2009 - 01/2003
2Neoplasm Metastasis (Metastasis)
05/2007 - 07/2004
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
05/2004 - 05/2004
1Renovascular Hypertension (Goldblatt Syndrome)
09/2008
1Diastolic Heart Failure
09/2008
1Ascites
11/2007
1Type 2 Diabetes Mellitus (MODY)
06/2006
1Endometriosis
01/2006
1Edema (Dropsy)
08/2005
1Serous Cystadenocarcinoma
08/2005
1Pregnancy-Induced Hypertension (Hypertension, Pregnancy Induced)
08/2005
1Clear Cell Adenocarcinoma
07/2005
1Mucinous Cystadenoma
07/2005
1Carcinogenesis
03/2005
1Lymphatic Metastasis
01/2005
1Congenital Heart Defects (Congenital Heart Defect)
05/2004
1Uterine Cervical Dysplasia
05/2004
1Trophoblastic Neoplasms (Trophoblastic Tumor)
12/2003

Drug/Important Bio-Agent (IBA)

12leucyl-cystinyl aminopeptidaseIBA
12/2021 - 01/2002
12Angiotensin IIIBA
11/2013 - 11/2002
11Glutamyl Aminopeptidase (Aspartyl Aminopeptidase)IBA
11/2013 - 11/2002
10Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)IBA
02/2010 - 05/2002
9Peptides (Polypeptides)IBA
09/2009 - 03/2003
8Complementary DNA (cDNA)IBA
01/2007 - 04/2003
7Oxytocin (Pitocin)FDA LinkGeneric
11/2013 - 04/2003
6AminopeptidasesIBA
01/2022 - 12/2003
6EnzymesIBA
09/2008 - 04/2003
6Proteins (Proteins, Gene)FDA Link
01/2007 - 04/2002
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
04/2005 - 12/2003
5Peptide Hydrolases (Proteases)FDA Link
08/2005 - 05/2004
4Paclitaxel (Taxol)FDA LinkGeneric
02/2010 - 11/2004
4AngiotensinsIBA
09/2008 - 06/2003
4Neprilysin (Neutral Endopeptidase)IBA
03/2005 - 04/2003
3Peptide Hormones (Polypeptide Hormones)IBA
01/2022 - 01/2004
3Hormones (Hormone)IBA
01/2022 - 01/2011
3Vasopressins (Vasopressin)IBA
11/2013 - 09/2003
3Formaldehyde (Formol)FDA Link
07/2005 - 01/2004
3ParaffinIBA
07/2005 - 01/2004
3Endothelin-1 (Endothelin 1)IBA
03/2005 - 08/2004
3Leucyl Aminopeptidase (Peptidase S)IBA
01/2005 - 08/2003
3Cystinyl AminopeptidaseIBA
03/2004 - 02/2003
2Magnesium Sulfate (Sulfate, Magnesium)FDA LinkGeneric
11/2013 - 01/2005
2SaltsIBA
09/2008 - 04/2005
2ubenimexIBA
07/2007 - 05/2007
2Insulin (Novolin)FDA Link
01/2007 - 03/2004
2Glucose (Dextrose)FDA LinkGeneric
01/2007 - 06/2006
2Carboplatin (JM8)FDA LinkGeneric
03/2006 - 11/2004
2ReninIBA
08/2005 - 06/2003
2Cadherins (E-Cadherin)IBA
08/2005 - 05/2003
2Conditioned Culture MediaIBA
03/2005 - 01/2005
1Biomarkers (Surrogate Marker)IBA
12/2021
1Angiotensin IIIIBA
01/2012
1Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
09/2008
1Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
09/2008
1CD13 Antigens (Alanine Aminopeptidase)IBA
05/2007
1Insulin ReceptorIBA
01/2007
1Leukemia Inhibitory FactorIBA
04/2006
1HLA Antigens (Human Leukocyte Antigens)IBA
04/2006
1A-factor (Streptomyces)IBA
03/2006
1Cisplatin (Platino)FDA LinkGeneric
03/2006
1Urea (Carbamide)FDA LinkGeneric
08/2005
1Naphazoline (All Clear)FDA LinkGeneric
07/2005
1candesartanIBA
04/2005
1Type 1 Angiotensin ReceptorIBA
04/2005
1Endothelin A ReceptorIBA
03/2005
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
03/2005
1Matrix Metalloproteinase 2 (Gelatinase A)IBA
03/2005
1Indomethacin (Indometacin)FDA LinkGeneric
01/2005
1BombesinIBA
01/2005
1Vasoconstrictor AgentsIBA
01/2005
1PlatinumIBA
11/2004
1Biological ProductsIBA
08/2004
1Chemokine CXCL12IBA
07/2004
1CXCR4 Receptors (CXCR4 Receptor)IBA
07/2004
1ethyl monochloroacetate (EMCA)IBA
07/2004
1Metalloproteases (Metalloproteinases)IBA
05/2004
1Antineoplastic Agents (Antineoplastics)IBA
05/2004
1ImmunosorbentsIBA
05/2004
1Oxytocin Receptors (Oxytocin Receptor)IBA
04/2004
1Docetaxel (Taxotere)FDA Link
12/2003

Therapy/Procedure

4Therapeutics
07/2005 - 01/2002
2Hysterectomy
01/2006 - 05/2004
2Drug Therapy (Chemotherapy)
11/2004 - 05/2004
1Molecular Targeted Therapy
01/2007
1Salpingo-oophorectomy
01/2006
1Estrogen Replacement Therapy
01/2006
1Neoadjuvant Therapy
01/2004
1Salvage Therapy
12/2003